Alkyl fluorides
Medchemexpress LLC BAY-678 | 675103-36-3 | 99.6% | 400.35 | 1 ML
BAY-678 is an orally bioavailable, highly potent, selective, and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC₅₀ of 20 nM. It has been nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC). It demonstrates significant efficacy in preclinical models of ALI and lung emphysema, showing anti-inflammatory and anti-remodeling actions. Additionally, it has shown beneficial pulmonary hemodynamic and vascular effects in models of PAH in rats and mice.
- Orally bioavailable and cell-permeable inhibitor of human neutrophil elastase
- Exhibits more than 2,000-fold selectivity in a panel of 21 serine proteases
- Shows significant efficacy in preclinical models of ALI and lung emphysema
- Demonstrates anti-inflammatory and anti-remodeling modes of action
- Beneficial pulmonary hemodynamic and vascular effects in models of PAH
eMolecules 307-24-4 | PERFLUOROHEXANOIC ACID | AstaTech | MFCD00198040 | 314.054 | C6HF11O2 | 98.000 | OC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F | 10g | 718057475
PERFLUOROHEXANOIC ACID | AstaTech | 307-24-4 | MFCD00198040 | 314.054 | C6HF11O2 | 98.000 | OC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F | 10g | 718057475
Medchemexpress LLC X-376 (Ensartinib) | 1365267-27-1 | 98.1% | 547.41 | 100 MG
X-376 is a potent and highly specific ALK tyrosine kinase inhibitor (TKI) (IC50=0.61 nM). It is a less potent inhibitor of MET (IC50=0.69 nM) and displays potent anti-tumor activity.
- Potent and highly specific ALK tyrosine kinase inhibitor
- Less potent inhibitor of MET
- Displays potent anti-tumor activity
Medchemexpress LLC GluN1(356-385) | 99.95% | 3415.90 | 10 MG
GluN1 (356-385) is an antigenic peptide against N-methyl-D-aspartate receptor (NMDAR) encephalitis. It reduces the density of surface NMDAR clusters in hippocampal neurons and can be used to study the pathogenesis of anti-NMDAR encephalitis.
- Antigenic peptide against NMDAR encephalitis
- Reduces density of surface NMDAR clusters in hippocampal neurons
- Used to study pathogenesis of anti-NMDAR encephalitis
- Related to peptide and derivatives, and peptide epitopes
- Applicable to neurological, eye or ear disease
- Associated with membrane transporter/ion channel, neuronal signaling, and iGluR pathways
Sigma Aldrich Fine Chemicals Biosciences Heptafluorobutyric anhydride >=98% | 336-59-4 | MFCD00000432 | 10AMP
Heptafluorobutyric anhydride >=98% | Purity: >=98% | Mol Wt: 410.06 | 336-59-4 | MFCD00000432 | 10AMP
Medchemexpress LLC Perfluorohexanoic acid (Undecafluorocaproic acid) | 307-24-4 | 99.90% | 314.05 | 500 MG
Perfluorohexanoic acid, also known as Undecafluorocaproic acid, is a biological molecule for research use only.
- High purity: 99.90%
- Molecular weight: 314.05
- Appearance: solid below 12°C, liquid above 14°C
- Color: colorless to off-white
- Formula: C6HF11O2
- Recommended storage: room temperature for 3 years; in solvent, -80°C for 2 years or -20°C for 1 year.
Medchemexpress LLC X-376 | 1365267-27-1 | 98.10% | 547.41 | 25 MG
X-376 is a potent and highly specific ALK tyrosine kinase inhibitor (TKI) with an IC50 of 0.61 nM. It is also a less potent inhibitor of MET (IC50=0.69 nM) and exhibits potent anti-tumor activity.
- Effective in inhibiting the growth of various cancer cell lines, including H3122 lung cancer cells (IC50: 77 nM), H2228 lung cancer cells (IC50: 57 nM), and SUDHL-1 lymphoma cells (IC50: 32 nM).
- Also inhibits SY5Y neuroblastoma cells, MKN-45 gastric carcinoma cells, HepG2 cells, and PC-9 lung cancer cell lines.
- Demonstrates substantial bioavailability and moderate half-lives in vivo.
- Significantly delays tumor growth in H3122 xenografts at a dose of 50 mg/kg bid, appearing well-tolerated without affecting mouse weight or causing compound-related toxicity.
Medchemexpress LLC LMP2A (426-434) | 152274-91-4 | 96.1% | 906.16 | 10 MG
LMP2A (426-434) | 152274-91-4 | 96.1% | 906.16 | 10 MG
Medchemexpress LLC Glun1 (356-385) | 99.95% | 3415.90 | 25 MG
GluN1 (356-385) is an antigenic peptide against N-methyl-D-aspartate receptor (NMDAR) encephalitis. It reduces the density of surface NMDAR clusters in hippocampal neurons and can be used to study the pathogenesis of anti-NMDAR encephalitis.
- Antigenic peptide against N-methyl-D-aspartate receptor encephalitis
- Reduces density of surface NMDAR clusters
- Suitable for studying anti-NMDAR encephalitis pathogenesis
- Inhibitor of ionotropic glutamate receptors
- Active immunization agent
Medchemexpress LLC Perfluoropentanoic acid (PFPeA) | 2706-90-3 | 98.0% | 264.05 | 100 G
Perfluoropentanoic acid (PFPeA) | 2706-90-3 | 98.0% | 264.05 | 100 G
Cayman Chemical 2H,2H,3H,3H-Perfluorodecanoic Acid, Purity: ≥80%, CAS: 812-70-4, 50 mg
A polyfluoroalkyl substance; has been found as a contaminant in freshwater reserves and marine seafood
eMolecules 307-24-4 | Perfluorohexanoic acid | Apollo Scientific | MFCD00198040 | 314.054 | C6HF11O2 | 98.000 | OC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F | 1g | 562457022
Perfluorohexanoic acid | Apollo Scientific | 307-24-4 | MFCD00198040 | 314.054 | C6HF11O2 | 98.000 | OC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F | 1g | 562457022
Matrix Scientific PERFLUOROHEPTANOIC ACID-25G
Perfluoroheptanoic acid, 98%; 25g,C7HF13O2, MFCD00039604, mw 364.06, [375-85-9]
Cayman Chemical Heptafluorobutyric Acid, Purity: ≥80%, CAS: 375-22-4, 50 g
A perfluoroalkyl substance; chronic topical administration on the ear increases liver and kidney weight in mice at 25 µl of a 3.75-15% v/v on the ear; induces multifocal hepatocyte necrosis and centrilobular hepatocyte hypertrophy at 7.5% v/v; increases serum cholesterol and ALP levels at 15% v/v; decreases serum urea nitrogen levels; has been found in marine life and as a contaminant in surface water
SPEX CERTIPREP LLC 3P n-Perfluoroheptanoic acid; 50 µg/mL in MeOH with 4 mole eq. NaOH; 1 mL
n-Perfluoroheptanoic acid; 50 µg/mL in MeOH with 4 mole eq. NaOH; 1 mL